Bioben Services

Bioben offers an interface between chemistry & technology to carry out synthesis from its conception to commercial manufacturing with cost effective production in a safe work environment and provides process optimization, cost reduction of existing process and scale up to deliver quality material from milligram quantities to multi-kilo scale. Bioben can also offer a range of APIs, chemical intermediates and building blocks for the Pharmaceuticals, biotech and chemical industries.

Bioben have acquired technical capabilities in scaling up complex chemical processes. Our collaborator pilot plant/Plant facilities are equipped with glass, glass lined and stainless steel reactors ranging from 50 L to 2000 L (maximum capacity of 2000 L) which can handle temperatures ranging from +120°C to –10°C., and are fully equipped to develop intermediates and final products, purpose to suit most client needs.

Custom Synthesis

Bioben specializes in complex multi-step custom synthesis for pharmaceutical industry. Synthesis of non-commercial organic chemicals Preparation of drugs, starting materials, intermediates and reference compounds and impurities with 50L, 100 L and 200 L All Glass Reactors with temperatures ranging from +120°C to –75°C (Liquid nitrogen). Delivers on mg to Kg scale Bioben offers a full range of services to meet the varying needs of our customers.

Do you need synthesis or re-synthesis of specific building blocks, monomers or scaffolds? Or synthesis of fragments, lead like or drug like compounds or analog/SAR sets?

Bioben are able to quote on a wide range of projects from mg to gram and higher scale. Compounds are synthesized to your specifications and analytical requirements. For larger projects, Bioben offers fee-for-service and FTE based collaborations.

Click Here to submit a Custom Synthesis project, or send an email to enquiry@bioben.in

Example Custom Synthesis Projects

  • Custom building blocks, monomers, scaffolds or fragments
  • Synthesis or re-synthesis of lead like or drug like compounds from ChemBridge or other sources or from published articles
  • Analogs for SAR studies or hit explosion
  • Hit to Lead libraries requiring individual compound synthesis or parallel synthesis

Medicinal Chemistry Service

Bioben offers medicinal chemistry as part of its custom synthesis service line. We help clients involved in developing compounds, specifically small organic molecules for the purpose of creating new medicines and therapies. Also known as discovery chemistry, we assist organizations understand Structure-Activity Relationships (SAR) in drug development through chemical structure modifications.

Our chemists have significant experience in exploratory, collaborative R&D synthesis. Our chemists are team-oriented and dedicated to provide the best possible service in support of your product research.

Click Here to submit a Medicinal Chemistry Service project, or send an email to enquiry@bioben.in

Contract R&D

Bioben can serve as your chemistry department or as a supplement to existing resources to maximize research productivity. Bioben offers collaboration in the discovery of novel compounds.

Bioben provides services with full confidentiality. Bioben provides timely, high quality delivery.

Synthesis of:

  • Reference compounds
  • Impurities
  • Pharmaceutical intermediates
  • Metabolites, Expertise:

Lab Scale: Cyanations, CBS Reductions, Carbonylations, LAH, BMS, Choloroformates, Azides, Metal Amides, Diazomethane, Carbon disulfide, Thiophosgene, Phosphines, Metal Amides

Pilot Plant Scale: Lithiations, Bromination, Oxidations, Nitrations, Resolutions, Suzuki Couplings, DIBAL-H, Bromine, PCl5, POCl3, KMnO4, Pd(PPh3)4 etc.

Plant Scale: Lithiations, Alkylations, Reductions, Alkyl Lithiums, Sodium Hydride, Raney Nickel, Borohydrides

Click Here to submit a Contract R&D Service project, or send an email to enquiry@bioben.in

Route development

We can offer the following services, all of which are underpinned by our strong policies on Intellectual Property (IP) protection, ensuring projects are handled in the strictest of confidence at all times.

  • Synthetic route development
  • Process optimisation
  • Process scale-up from grams through to Metric Tonnes
  • Exclusivity if required
  • Full analytical support including HPLC, GC-MS and NMR

For products where a manufacturing process already exists. In addition to the services mentioned above, we also provide a specialist raw material sourcing service (at no additional cost) to ensure that, wherever possible, we only use sources of high quality materials at competitive market prices.

We have an excellent track record of solving complex organic synthesis challenges for our customers and projects can be based on full-time equivalents (FTE) or daily rates.

We are more than willing to test any newly designed synthesis route. We gladly contribute to synthesis development by finding the right experimental conditions and purification procedures for each step. Since our chemists are motivated by obtaining high yields, they take pride in adjusting and improving reaction conditions creatively, reaching the maximum level of success in any given synthesis route.

Click Here to submit a Route development Service project, or send an email to enquiry@bioben.in

Process Chemistry Solutions

Bioben Major’s reputation for providing solutions and expertise to solve our clients most difficult and challenging issues is unparalleled. Here are a few of the problems we solve daily for our clients:

  • Low overall yield or high dilutions
  • Difficult removal of metals to ICH limits
  • Removal of dangerous or hazardous reagents or intermediates
  • Difficulty eliminating chromatography from intermediates or API
  • Difficulty crystallizing intermediates or API

Route Scouting

Bioben also provides comprehensive process research services aimed at scouting alternate routes to existing molecules. This can range from complete route development to targeted research on a single challenging step in a synthetic pathway.

Click Here to submit a Process Chemistry Service project, or send an email to enquiry@bioben.in

For universities

Bioben provides custom synthesis of organic compounds for the chemical to universities and research institutions. We offer starting materials, intermediates, reference compounds, and derivatives of lead compounds. Compounds are made to order in scales ranging from milligrams to several kilograms.

We specialize in small organic compounds, natural products, heterocycles, nucleosides, and amino acids. Our staff is capable of handling difficult synthetic assignments and providing high quality, on-time, and confidential services. We are developing an inventory of compounds that are not readily available elsewhere, and appreciate suggestions from you and your staff about products that we might offer.

Click Here to submit a Process For universities project, or send an email to enquiry@bioben.in

Microbiology and molecular biology

Microbiology

Bioben microbiology division has a good platform to do the application oriented research technologies for studying and identifying microorganisms. Techniques have adapted for rapid identification & characterization of microorganisms as per WHO.

Molecular Biology

At Bioben scientists strive to develop stable recombinant proteins expressing cell lines for application in drug discovery research.

Services

Gene cloning and gene expression studies Recombinant proteins expressing stable cell line development

Click Here to submit a Process Microbiology and molecular biology project, or send an email to enquiry@bioben.in

In Vitro Biology

Bioben has excellent facility of laboratory to perform a variety of biochemical and cell based assays against target enzymes, GPCR’s, and transporters. Bioben developed methodologies, which is acceptable as per USFDA on target validation and mechanism studies

  • Assay Development & Validation (In-vitro)
  • Biochemical & cell based assay method development & validation
  • Statistical support
  • Algorithms for data processing and quality evaluation

Click Here to submit a Process in Vitro Biology project, or send an email to enquiry@bioben.in

In Vitro Biology

Bioben supports both integrated preclinical discovery programs and fee-for-service projects and delivers quality and reproducible results with a quick turnaround time. DMPK basically comprises in vitro, in vivo, met-ID and pre-formulation groups managed by experienced and scientific people.

Bioben developed a validated permeability studies Caco2 & MDCK cells with basic facility & expert scientific team. This division guides the discovery projects by trouble shooting the scientific issues and offer changes on scaffolds to drive the discovery projects in a right direction.

Click Here to submit a Process in Vitro Biology project, or send an email to enquiry@bioben.in

Herbal formulation and marketing

Bioben formulate the human & veterinary products, tested in preclinical studies, registered, licensed and marketed in the name of the company globally. Bioben provides the platform for the development of genuine, effective, safe, biological active and consistent human health care new products. Our formulation team has expertise in development of appropriate dosage forms to maximize product quality throughout the product lifecycle.

  • Antidiabetic, antiviral products & anticancer monoherbal and polyherbal formulations
  • General Health products: Immune enhancers, Aphrodisiac, energy drinks, Hepatoprotective supplements, multivitamin supplements, Rejuvenator, Kidney disorders
  • Cosmetics- Herbal facials, fairness creams, anti wrinkling, Shampoos, acne creams, skin cream
  • Oral Care & Hygiene products – Gum tone powder, Hand wash, moisturizer, Health drinks, antidandruff
  • Veterinary products- Shampoos wound healing creams/sprayers, anti stress products, ant lice shampoo, probiotics, Bolus, antiseptic creams/sprays, Poultry products
  • Development of stable dosage forms, pilot scale to commercial Scale up trials
  • Marketing of herbal products, Extracts, Phytochemicals, Phyto reference standards

Click Here to submit a Process in Vitro Biology project, or send an email to enquiry@bioben.in

Herbal formulation and marketing

Biotechnology

Bioben is taking custom based research activities to develop methodologies, research technologies, trouble shooting in experiments, analysis of the raw material and finished products

  • Biofuel Research/ Downstream processing
  • Monoclonal antibody /Biosimilar
  • Research oriented methodologies to ensure accuracy and timely release of reports.
  • Chemical analysis of test material (Raw material), food material, water, syrups, tablets or any pharmaceutical samples Metal detection, Total organic carbon, Sulfate, Nitrogen estimation, Total residual chlorine, Calcium, Magnesium, total solids etc Effluent sewage treatment, BOD, COD, Dissolved oxygen tests

Environment Projects:

Contracting environmental studies with various industries and Pollution control board like sewage management & treatment, Air monitoring, chemical analysis, pollutants analysis, pollution controlling in air, water & soil.

Training

  • Collaborative Project proposals, Experiment planning, Data interpretation/Project report submission
  • We undertake Student Projects / Dissertation for BE (Biotech), M.Sc., M.pharm, MBBS, MD and Ph.D. using well validated methods /protocols/SOPS.
  • Short term courses in cell Biology/Chemistry/Animal Studies

Click Here to submit a Process Environment project, or send an email to enquiry@bioben.in

Send us an enquiry

Call on : 91 8050130335

Email : info@bioben.com

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